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KMID : 0370220030470010037
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Yakhak Hoeji
2003 Volume.47 No. 1 p.37 ~ p.45
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Anticancer Activity of Monoterpenes and the Changes of Enzymes Activities Responsible for the Conversion of Reactive Oxygen Species
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조용선/Cho YS
김수진/박시원/Kim SJ/Park SW
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Abstract
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The present study was undertaken to investigate the anticancer activity of monoterepenes in the animal and the cancer cell line tests. Both of the noncyclic and cyclic monoterpe nes showed significant life prolonging effects on ICR mouse with abdominal cancer induced by Sarcoma 180 cells up to 67.4% and 63.5% in case of linalool and geraniol, respectively: Linalool and geraniol also exhibited very excellent cytotoxicity against L1210 leukemic cells with IC50 value of 0.32 μg/ml in 5 days culture condition. In the presence of linalool and geraniol, the generation of 02- ion were found to be increased proportionally to the cytotoxicity arisen from these monoterpenes. Furthermore, the antioxidant enzymes activities such as superoxide dismutase (SOD) and glutathione peroxidase (GPx) responsible for the conversion of 02- ion to H2O2 and then to H2O augmented remarkably by linalool and geraniol. All data put together it can be postulated that monoterpenes may kill abdominal cancer cells of ICR mouse probably by activating anticancer system of the bodyl whereas the death of L1210 cells may be due to the detrimental attacks of reactive oxygen species (ROS) including O2- in spite of antioxidant enzymes activities to overcome the ROS attacks.
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